Comprehensive Solutions for Animal Health Biologics
Cell Line Development
- Gene to GMP Solutions
- 200+ cell lines, 3 commercially used
- Cell line development for canine, feline mAbs and fusion proteins
- Familiarity with USDA and CVB requirements
- Royalty-free CHO-DG44 and CHO-GS and CHO-GS FUT∞KO Platforms
- 8 g/L titers with assured product quality
Protein Sciences
- Expertise in the production of canine, feline, equine, porcine and bovine antibodies/proteins
- Experience with diverse formats including IgG, BsAbs, scFv, IgM and chimeric mAbs
Analytics
- Ag-Ab binding affinity
- Enzyme activity
- Cell-based assays
- Isothermal stability
- HPLC, ELISA, A280
- SEC-MALS
- CE-SDS and more
Process Development & Characterization
- Fully automated Ambr® 250 Bioreactors
- Multifactorial DOE
- Upstream PD for higher titers and shorter timelines
- Robust scalable upstream development
GMP Manufacturing
- Single-use bioreactors 50L, 200L, 500L, and 2,000L with total expansion capacity to 23,000L
- High productivity with minimum titers of 4 g/L for most mAbs and BsAbs; scaling up to 25 g/L after process intensification
- DS Production Ready and DP Underway
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